I have been taking this for awhile for my neuropathy. It’s seems to be working because I don’t have those symptoms anymore and my legs are stronger! But I am also taking a B12 supplement and some magnesium. When I first took this magnesium supplement the difference was incredible! And shortly after that I started on a special type of B12 (Methycobalamin) and Benfotiamine. So I am not sure which is working the best. But, I am continuing on all of them.