Neuroinflammation

What Is Neuroinflammation?

Neuroinflammation happens when the brain’s immune cells, known as microglia and astrocytes, become too active. While a little inflammation helps protect the brain, too much can damage brain cells and disrupt normal brain function. This can lead to mood changes and mental health issues like depression and anxiety.

If left untreated, neurodegeneration can worsen and lead to dementia, a condition marked by memory loss, confusion, and difficulty with daily tasks. Over time, brain cells die, impairing cognitive and motor functions. Early treatment is key to slowing this decline and maintaining quality of life.

A study published in Biological Psychiatry found that people with depression had higher levels of inflammatory markers in their brains than those without depression (Felger & Miller, 2016). This suggests that neuroinflammation may be a key factor in mood disorders like depression and anxiety.

How Does Neuroinflammation Affect Mood?

• Damages Brain Cells - Too much inflammation releases harmful chemicals that can damage or even kill neurons (brain cells).
• Messes With Brain Chemicals - Inflammation can throw off the balance of important brain chemicals like serotonin and dopamine, which are responsible for regulating mood.
• Reduces BDNF Levels - Brain-Derived Neurotrophic Factor (BDNF) is a protein that helps keep neurons healthy and supports brain flexibility. Inflammation can lower BDNF, making it harder for the brain to repair and grow.

Concerned About Neuroinflammation?

Individuals now better understand the effects of inflammation to preserve brain health and combat neurodegeneration. Here’s how it can benefit people facing these challenges:

• Early Cognitive Decline - Individuals noticing early signs of cognitive decline, such as memory issues, brain fog, or trouble focusing, may find natural ways to help enhance mental clarity and slow further cognitive deterioration.
• Neurodegenerative Conditions - For those managing or at risk of conditions like Alzheimer's or dementia, an herbal and lifestyle plan provides targeted support aimed at protecting brain cells and promoting long-term cognitive health.
• Mood Imbalances Related to Brain Health - As neurodegeneration often leads to mood disorders like anxiety or depression. The goals should be to stabilize emotional well-being by reducing neuroinflammation and supporting brain function.
• Chronic Inflammation and Aging - Individuals concerned about the effects of aging or chronic inflammation on the brain may benefit from the anti-inflammatory properties of herbs, diet, movement and stress management, which helps protect against accelerated neurodegeneration.
• Brain Injury Recovery - For those recovering from traumatic brain injuries, specific herbs and nutrients aid in neuroregeneration and help mitigate the long-term effects of injury on cognitive health.

Natural Ways to Fight Neuroinflammation

One way to reduce neuroinflammation is by using certain herbs that have been shown to support brain health and reduce inflammation. The following herbs have been used traditionally for centuries and are now supported by scientific research for their benefits in reducing neuroinflammation:

Turmeric (Curcuma longa)

• What It Is? A bright yellow spice often used in cooking.
• How It Helps - Contains curcumin, a powerful anti-inflammatory compound. Curcumin helps reduce brain inflammation, boosts BDNF levels, and protects neurons from damage.

Boswellia (Boswellia serrata)

• What It Is? A resin extracted from the Boswellia tree, also known as frankincense.
• How It Helps - Boswellia contains compounds that reduce neuroinflammation and protect neurons from further damage. It can also improve mood and cognitive function.

Gotu Kola (Centella asiatica)

• What It Is? A herb commonly used in traditional medicine to improve memory, musculoskeletal health and brain function.
• How It Helps - Gotu Kola boosts brain circulation, supports neuron growth, and improves memory and cognitive function.

Bupleurum (Bupleurum falcatum)

• What It Is? A traditional Chinese herb known for its ability to reduce inflammation and support mood by regulating the body's stress response.
• How It Helps - It helps protect brain cells and boosts brain-derived neurotrophic factor (BDNF), which supports learning, memory, and overall brain health.

Introducing NeuroRegenex

To help people take advantage of these powerful herbs, MediHerb has created a new product called NeuroRegenex. This supplement is designed to support brain health and reduce neuroinflammation using a unique blend of herbs.

What Makes NeuroRegenex Special?

NeuroRegenex leverages the synergy of four key herbs—Gotu Kola, Turmeric, Boswellia, and Bupleurum—to support brain health and reduce neuroinflammation. It uses FenuMAT™ Technology, developed under the leadership of Kerry Bone at MediHerb, to improve the absorption of curcuminoids and boswellic acids.

Proprietary extracts CurQfen™ (curcumin) and BosQfen™ (Boswellia) extracts, further enhance the formula’s effectiveness, making NeuroRegenex a top choice for cognitive support and brain health.

Innovative delivery technologies like FenuMAT™ are transforming how herbal constituents are absorbed and utilized. FenuMAT™ uses natural prebiotic fibers from fenugreek seeds to create a protective hydrogel around active compounds, significantly enhancing the bioavailability of fat-soluble ingredients such as curcumin and boswellic acids, which are typically hard to absorb. This system allows the compounds to remain intact longer in the digestive tract, promoting better absorption and enabling them to cross the blood-brain barrier (BBB) more effectively, optimizing their therapeutic impact.

Early Research on NeuroRegenex

A research study was recently conducted at Western Sydney University, which tested the effectiveness of herbal ingredients in reducing neuroinflammation, a process where the brain's immune cells (microglia) become activated and release harmful substances like unbalanced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). These substances can damage brain cells and contribute to conditions like depression, anxiety, Alzheimer's, and other neurodegenerative diseases.

In the study, researchers used in vitro tests (experiments done in a lab, not on living humans) to see how well certain herbs could reduce the production of NO and TNF-α. The tests measured IC50 values, which indicate how much of a substance is needed to reduce a specific biological activity by 50%. In this case, they tested how much herb extract was needed to reduce NO and TNF-α production by 50% in brain immune cells.

Gotu Kola and Bupleurum, combined with the CurQfen™ (curcumin) and BosQfen™ (Boswellia) extracts, showed strong effects, with IC50 values of 14 μg/mL for NO and 53 μg/mL for TNF-α. This means these herbs were able to effectively inhibit neuroinflammation at these concentrations.

Unmatched Potency for Cognitive and Physical Inflammation

NeuroRegenex is one of the most potent and advanced brain health supplements on the market today, significantly outpacing standard products and backed by cutting-edge research.

For instance, the Turmeric in NeuroRegenex is not your typical turmeric extract—it's 55 times more concentrated, meaning it delivers a massive 135 mg of curcuminoids per dose. These compounds are known for their powerful anti-inflammatory and neuroprotective effects. Most turmeric supplements on the market only offer a fraction of this potency, and often without the enhanced bioavailability that NeuroRegenex provides through FenuMAT™ Technology. In fact, research shows that CurQfen™, the proprietary curcumin extract used, is up to 45 times more bioavailable than unformulated curcumin, meaning your body can absorb and use it far more effectively.

Similarly, the Boswellia extract in NeuroRegenex is 23 times more concentrated than its raw form, delivering potent boswellic acids, known to reduce brain inflammation and protect against neurodegeneration. Standard Boswellia products often provide far lower concentrations, resulting in less effective doses.

NeuroRegenex doesn't stop there. Gotu Kola and Bupleurum, two additional powerhouse herbs, are formulated with similar potency, making them far more effective than what you'll find in typical supplements. Combined, these herbs are proven to boost brain health, reduce neuroinflammation, and improve cognitive function.

While many products may rely on less concentrated forms of these herbs or lack the technology to improve absorption, NeuroRegenex stands out with its potent doses and advanced delivery system, ensuring maximum therapeutic benefit. For anyone serious about protecting and enhancing brain health, NeuroRegenex offers unmatched potency and effectiveness.

The Targeted NeuroRegenex Protocol

NeuroRegenex is designed with a phased approach to tackle neuroinflammation and support whole-body wellness. By following these carefully structured phases, you can address neurodegeneration aggressively in the early stages while maintaining long-term brain health and reducing inflammation throughout the body. Whether you're managing existing issues or focusing on prevention, the phased protocol ensures you receive the optimal dosage at each stage to protect both your cognitive and musculoskeletal health.

Phase 1: Intensive Phase (6 tablets/day for 3 months)

During this phase, the high dosage helps aggressively target neuroinflammation, which is often at the root of neurodegenerative conditions. By supporting both brain and whole-body inflammation, the herbs in NeuroRegenex also aid in reducing musculoskeletal discomfort and improving overall mobility.

• Dosage: 6 tablets per day
• Duration: 3 months
• Total Bottles Needed: 9 bottles

Phase 2: Maintenance Phase (4 tablets/day for 2 months)

As you move into the maintenance phase, the focus shifts to sustaining the progress made during the intensive phase by continuing to reduce inflammation and promote neuroprotection. This dosage not only supports cognitive function but also continues to ease whole-body inflammation, benefiting joint health and muscle recovery.

• Dosage: 4 tablets per day
• Duration: 2 months
• Total Bottles Needed: 4 bottles

Phase 3: Long-Term Support (2 tablets/day ongoing)

The long-term support phase is designed to maintain brain health, prevent future neurodegeneration, and keep inflammation at bay. By promoting ongoing whole-body balance, this phase ensures continuous support for both mental clarity and musculoskeletal health, preventing flare-ups in chronic inflammation-related conditions.

• Dosage: 2 tablets per day
• Duration: Ongoing
• Total Bottles Needed: 1 bottle/month

Lifestyle Changes

In addition to taking herbal supplements, making some changes to your daily habits can also help reduce neuroinflammation.

Healthy Diet

• Eat Omega-3 Rich Foods - Such as salmon, nuts (including walnuts) and flaxseeds.
• Antioxidant-Rich Foods - Berries, dark leafy greens (get your salads in), and brightly colored vegetables help reduce inflammation.
• Avoid Processed Foods - Foods high in sugar and refined carbs can increase inflammation in the brain and body.

Exercise Regularly

Physical activity reduces inflammation and boosts BDNF levels, helping the brain function better. Aim for at least 30 minutes of exercise most days of the week.

Manage Stress

Chronic stress can increase inflammation. Try activities like meditation, yoga, or deep breathing to lower stress levels.

Get Enough Sleep

Sleep is essential for brain health. A good night’s sleep allows the brain to repair itself and reduces inflammation.

Conclusion

Neuroinflammation may be a hidden cause of mood disorders like depression and anxiety. By addressing neuroinflammation through diet, movement, sleep and natural herbs like Turmeric, Boswellia, Bupleurum, and Gotu Kola—that are in innovative products like NeuroRegenex—you can take steps to support your brain health naturally.

Always remember to talk to a healthcare professional before starting any new supplement or treatment.

References

• Felger, J. C., & Miller, A. H. (2016). Inflammation as a Mechanism in Mood Disorders - Review and Recommendations for Future Research. Biological Psychiatry, 78(9), 603–615. doi -10.1016/j.biopsych.2015.05.015
• Ahmed, H., Mohamed, E. A., El-Dsoki, S. (2014). Evidences for the promising therapeutic potential of Boswellia serrata against Alzheimer’s disease: Pre-clinical study. International Journal of Pharmaceutical and Pharmacological Sciences, 6(11), 384-392.
• Alluri, V. K., Kundimi, S., Sengupta, K., Golakoti, T., & Kilari, E. K. (2020). An anti-inflammatory composition of Boswellia serrata resin extracts alleviates pain and protects cartilage in monoiodoacetate-induced osteoarthritis in rats. Evidence-Based Complementary and Alternative Medicine, 2020, 7381625.
• Bone, K. M., & Mills, S. Y. (2013). Principles and practice of phytotherapy: Modern herbal medicine (2nd ed.). Elsevier.
• Chopra, R. N., Chopra, I. C., Handa, K. L., & Kapur, L. D. (1958). Chopra’s indigenous drugs of India (2nd ed.). Academic Publishers.
• Günther, B., & Wagner, H. (1996). Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban. Phytomedicine, 3(1), 59-65.
• Park, W. H., Kang, S., Piao, Y., Pak, C. J., Oh, M. S., & Kim, J. (2015). Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB. Journal of Ethnopharmacology, 174, 37-44.
• Su, J., Pan, Y. W., Wang, S. Q., Li, X. Z., Huang, F., & Ma, S. P. (2020). Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation. International Immunopharmacology, 80, 106181.
• Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., & Li, X. (2006). Curcumin reverses the effects of chronic stress on behavior, the HPA axis, and BDNF expression. Brain Research, 1122(1), 56-64.
• Arkay Natural Ingredients. Technology [Internet]. Kerala: Arkay Natural Ingredients; 2021 [cited 2022 Feb 09]. Available from: https://www. curqfen.net/technology/#
• Kumar D, Jacob D, Subash PS, Maliakkal A, Johannah NM, Kuttan R, et al. Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: a randomised double-blind crossover study. J Funct Foods. 2016 Apr 1;22:578-87.
• Sudheeran, S. P., & Maliakel, B. (2016). Safety, tolerance, and enhanced efficacy of a bioavailable formulation of curcumin with fenugreek dietary fiber. Journal of Clinical Psychopharmacology, 36(3), 236-243.

Statement on Research and Efficacy

The information provided in this article is based on a thorough review of scientific studies and expert insights regarding the ingredients and products discussed, including Turmeric, Boswellia, Gotu Kola, and Bupleurum. Research suggests that these herbs may offer significant benefits in supporting brain health, reducing neuroinflammation, and promoting overall well-being. However, it is important to note that individual results may vary, as the effectiveness of these supplements and dietary practices can be influenced by factors such as personal health conditions, lifestyle, and diet. While we reference studies that investigate these same herbs, the specific formulations and extracts mentioned in this article may differ from those used in the cited research.

Disclaimer

The statements made in this article have not been evaluated by the Food and Drug Administration (FDA). The products mentioned are not intended to diagnose, treat, cure, or prevent any disease. While the research referenced provides promising insights, it is not exhaustive, and the conclusions drawn should not be taken as definitive. Individuals considering these supplements or dietary changes should consult with a healthcare professional to determine what is appropriate for their specific health needs. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition or treatment.